William and Anne had fifteen children. 

With her husband, their children and some of his relatives, she arrived in Boston in 1634. Because of her radical religious teachings among the women of the colony, she was banished from Massachusetts in 1637-38.  She found temporary refuge in Rhode Island, where her husband died in 1642.

The Massachusetts colony was growing rapidly, Anne feared her home might soon be under the control of Massachusetts.  Anne moved to Long Island, New York, controlled by the Dutch.  The Dutch governor had aroused the enmity of the Indians and in 1643 an attack was made on the settlement. 
Anne and six of her children were killed in the attack.  Her youngest daughter was taken into captivity and not recovered for four years.